![]() However, since zolpidem was approved for medical use, an ever-increasing number of case reports describe abuse or dependence complications. 3 Thus, zolpidem is considered to have fewer adverse reactions than benzodiazepines. 2 Classical benzodiazepines have a non-specific affinity for the BZ1 (ω1) and BZ2 (ω2) receptors of the GABAA receptor. 1 Compared with traditional benzodiazepines, zolpidem is a powerful selective agonist of the ω1 receptor subtype of the γ-aminobutyric acid A (GABAA) receptor complex. Zolpidem, a non-benzodiazepine hypnotic agent, is recommended in guidelines as a first-line treatment for insomnia: ‘We suggest that clinicians use zolpidem as a treatment for sleep onset and sleep maintenance of insomnia (vs no treatment) in adults’. This case suggests that the cerebellum plays a role in the euphoria induced by high zolpidem doses and provides clues for further research. However, the prefrontal and parietal lobes’ electrical signal activity showed a tendency to recover to a normal state as the withdrawal time progressed to completion. ![]() Before undergoing detoxification, her MEG results indicated that cerebellar electrical signal activation increased when taking high zolpidem doses. To explore the neural mechanisms of the euphoric effect caused by high-dose zolpidem, we performed repeated magnetoencephalography (MEG) recordings. Her diagnoses were zolpidem dependence and a depressive episode induced by substance abuse. She reported subjective effects of euphoria, intense craving and the inability to stop drug ingestion. This article reports the case of a female zolpidem-dependent patient who presented with 6 years of daily use of 400–1400 mg of zolpidem. ![]() We were especially interested in the cases of dependence that presented a paradoxical ‘euphoric’ effect of zolpidem. However, after zolpidem was approved for medical use, an increasing number of case reports have described abuse or dependence complications. Initially, zolpidem, a non-benzodiazepine hypnotic agent, was considered to have fewer adverse reactions than traditional benzodiazepines.
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